Metorvast (Atorvastatin Calcium)
It is used to reduce LDL - Cholesterol, apolipoprotein B and trigylycerides and to increase HDL- cholesterol in the treatment of hyperlipidaemias including hypercholesterolaemias and combined (mixed) hyperlipidaemia (type II a or llb hyperlipoproteinaemias), hypertrigylceridaemia (type IV) and dysbetalipoproteinaemia (type III); can also be effective as adjunctive therapy in patients with homozygous familial hypercholesterolaemia who have some LDL - receptor function.
Dosage and Administration
IN ADULTS : The usual initial dose is 10 to 20mg once daily; an initial dose of 40mg daily may be used in patients who require a large reduction in LDL - Cholesterol. The dose may be adjusted at intervals of 4 weeks up to a maximum of 80 mg daily.
For Patients taking ciclosporin: maximum dose 10mg daily
For patients taking clarithromycin - initial dose 10mg once daily and maximum dose 20mg once daily.
For patients taking ritonavir - boosted lopinavir or ritonavir-boosted saquinavir - doses above 20mg once daily should be used with caution.
In Children and Adolescents- in aged 10 to 17 years with hypercholesteroaemia or combined (mixed) hyperlipidaemia, use orally in an initial dose of 10mg once daily, adjusted if ncecessary at intervals of at least 4 weeks to a maximum dose of 20mg once daily or as prescribed by a physician.